Chondrocyte subtype
Web(A) UMAP plots of various chondrocyte subtypes in human osteoarthritic knee joints. Colors indicate clusters of various cell types with distinct gene expression profiles. (B) Feature plots... WebNov 15, 2024 · Chondrocyte is the only cell type present in mature cartilage and is responsible for repairing damaged cartilage tissue [ 4 ]. Dysfunction of chondrocytes will result in degradation of the matrix, cell death and total loss of cartilage integrity [ 5 ].
Chondrocyte subtype
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WebApr 11, 2024 · HIGHLIGHTS who: Veronica Panichi and collaborators from the Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Laboratorio di Patologia delle Infezioni Associate all`Impianto, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy have published the … Notch1: a novel player in the molecular crosstalk underlying articular chondrocyte … WebJun 10, 2024 · Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Aimy Sebastian Lawrence Livermore National Laboratory, Physical and Life Science Directorate, Livermore, CA 94550, USA. Author profile Search articles by ORCID
WebChondrocyte trajectories analysis and IHC staining revealed that transcription factors including TCF4 were found to be highly up-regulated during the occurrence of SIFK, which might drive the reactive formation of cartilage and fibrous tissue and the activation of endochondral ossification. ... (GSE104782) data, 14 since the chondrocyte subtype ... WebNov 15, 2024 · Results: In this study, we characterized the single-cell expression profiling of 480 chondrocyte samples and found hypertrophic chondrocyte (HTC), homeostatic chondrocyte (HomC) and fibrocartilage chondrocyte (FC) respectively. The results of GO and KEGG analysis showed the candidate marker genes made specific function in these …
WebChondrocyte subtypes identified in mouse cartilage based on the expression of chondrocyte markers Col2a1, Acan, and Sox9 are shown in black oval. (D) Expression of chondrocyte markers Sox9... WebElucidating the molecular and functional profiles of various chondrocyte subtypes and understanding the interplay between these chondrocyte subtypes and other cell types in the joint will greatly ...
WebMechanical stress protects against chondrocyte pyroptosis through lipoxin A 4 via synovial macrophage M2 subtype polarization in an osteoarthritis model. Our previous study …
WebMar 9, 2024 · Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin during different intensities of treadmill exercise in a rat OA model and the anti-inflammatory and antipyroptosis mechanism of irisin in OA chondrocytes. lanttien 4WebJan 6, 2024 · Using single-cell RNAseq (scRNA-seq) data from adult mouse knee joint cartilage, we also determined that mature chondrocytes robustly express Loxl2, Loxl3, and Plod2, whereas Lox expression was more restricted to immature chondrocytes/mesenchymal progenitors ( Figure S3B ). lanttien nelonenWebFeb 21, 2024 · Characterization of Chondrocyte Subtypes. Chondrocytes secrete ECM such as collagen and proteoglycan, which are required for the NP’s structure and … lan tsnWebOct 11, 2011 · Chondrocyte hypertrophy and development of articular cartilage are the major histologic features of femoral head cartilage development (Fig. 2). The prototypic … lantsman melissaWebSome HIFs participate in the occurrence and development of OA by mediating apoptosis. Different HIFs subtypes have different effects on chondrocyte apoptosis in a hypoxic environment. For example, HIF-1α can inhibit chondrocyte apoptosis, while HIF-2α can promote chondrocyte apoptosis in the hypoxic environment. lanttu hiilihydraatitWebApr 4, 2024 · The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively … lanttien 2WebOct 11, 2011 · Cartilage is a unique tissue characterized by an abundant extracellular matrix (ECM) 1 and a single cell type, the chondrocyte. However, the permanent hyaline cartilage, which provides the articulating surfaces of long bones and vertebrae, and the transient growth plate cartilage responsible for endochondral bone growth are uniform in neither … lanttukiusaus