Cisplatin hearing loss thesis

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August undefined, 2024

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … WebCisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy …

A Study of Treatment for Medulloblastoma Using Sodium …

WebCISPLATIN-INDUCED OTOTOXICITY: THE CURRENT STATE OF OTOTOXICITY MONITORING IN NEW ZEALAND _____ A thesis submitted in partial fulfilment of the … WebApr 17, 2024 · For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. Reported rates of cisplatin … the rams head langley park

Chemotherapy and hearing loss: Until now, an unquantified risk

WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... WebBackground: Sensorineural hearing loss is a well-known side effect of cisplatin (CDDP). There is limited research on the effect of dosing, infusion times, and schedules of cisplatin administration and their impact on hearing loss. Methods: A retrospective review of 993 pediatric patients’ medical and audiological sign shop auburn maine

Subclinical diagnosis of cisplatin-induced ototoxicity with …

Cisplatin and hearing loss - See why it causes hearing loss - Hear …

WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. WebAug 25, 2024 · Platinum containing chemotherapeutic agents are associated with cochleotoxicity, characterized by high frequency hearing loss. Cisplatin and related … the rams head menuWeb• Investigating molecular mechanisms underlying cisplatin and noise-induced hearing loss • Determining the role of transplatin as an … the ramsey show podcast call in hours

"WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

CISPLATIN-INDUCED OTOTOXICITY. PHARMACOKINETICS, …

WebSep 24, 2024 · As cisplatin is an effective treatment for cancer, researchers have focused on finding ways to counteract the associated hearing loss. Combination therapies, where a protective compound (otoprotectant) such as antioxidants, anti-inflammatories, and steroids are administered alongside cisplatin, aim at decreasing the probability of the patient ... WebHearing loss induced by cisplatin or aminoglycosides is generally bilateral and begins at high frequencies, extend-ing to lower frequencies with prolonged treatment. …

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WebHigh-dose cisplatin treatment: hearing loss and plasma concentrations. Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) … WebJan 26, 2024 · A New Approach to Researching Cisplatin-Induced Hearing Loss. The new study differs from previous research because it is a comprehensive look at the pharmacokinetics, or concentration, of the …

WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … WebCISPLATIN-INDUCED HEARING LOSS IN CHOP KO MICE 2 Abstract Cisplatin is a chemotherapeutic drug that causes hearing loss, and the mechanisms of its ototoxicity …

WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients. WebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term …

WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely.

WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic … sign shop cincinnati ohWebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … sign shop business cardsWebhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved … sign shop in sandy oregonWebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge … the rams head glasgowWebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. … sign shop columbus ohioWebJun 1, 2024 · Hearing loss likely occurs in all cancers that are treated with cisplatin. Cisplatin is the most ototoxic drug in clinical use. It also happens to be a fantastic … the rams head prestonWebDec 18, 2024 · December 18, 2024. Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear. sign shop corner brook nl