Cisplatin resistance mechanism

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August undefined, 2024

WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at ...

Cisplatin in cancer therapy: molecular mechanisms of action

WebThe majority of cisplatin DNA lesions are repaired by the nucleotide excision repair (NER) system [ 79, 80]. One proposed mechanism for cisplatin resistance involves high expression of the high-mobility group box protein 1 (HMGB1) in TGCT cells [ 81]. WebFeb 25, 2024 · Autophagic flux in cisplatin-resistant ovarian cancer cells is caused by cisplatin. At present, the cytoprotective function of autophagy in cancer cells is considered a potential chemotherapy resistance mechanism. Most studies have suggested that targeting autophagy-related molecules may increase the chemosensitivity of cancer cells … phil\\u0027s still northport wi

Molecular mechanisms of cisplatin resistance - PubMed

WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the epithelial to mesenchymal transition. Conclusions. We identified gene signatures in resistant TNBC subtypes indicative of mechanisms of cisplatin. Our results indicate … WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, … WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase … phil\u0027s steakhouse treasure island las vegas

New Insights into Mechanisms of Cisplatin Resistance: …

Cisplatin: The first metal based anticancer drug - PubMed

WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the … tshwane west tvet collegeWebDDP has gradually become the standard chemotherapy method for chronic lung adenocarcinoma and postoperative grade II and III lung adenocarcinoma. 8 Although lung adenocarcinoma reacts well in the initial stage of standard cisplatin chemotherapy, significant DDP resistance develops before chemotherapy (primary resistance) or … tshwantshiso

"WebSep 9, 2014 · Another resistance mechanism to cisplatin and oxaliplatin is increased glutathione concentration, which inactivates platinum compounds before DNA damage occurs. Metallothioneins are small cysteine-rich proteins involved in metal detoxification and may play a role as stress proteins in response to platinum complexes. 76 Once inside … " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

Molecular mechanisms of cisplatin resistance in bladder cancer

WebApr 13, 2024 · YTHDF1 interacts with the binding motif of GLS1 and increases glutamine uptake to enhance glutamine metabolism in cisplatin-resistant CRC cells. The inhibition of GLS1 leads to an increased sensitivity to cisplatin-induced cell death and YTHDF1 is also a potential target in overcoming resistant colon cancers . In gastric cancer, YTHDF2 … WebJan 1, 2016 · Cisplatin is an alkylating agent capable of forming adducts with macromolecules, particularly with N7 atoms of purine nucleobases. This results in inter- and intra-strand DNA cross-links that bring induce cell cycle arrest mainly in the G 2 /M checkpoint ( Yuan et al., 2003 ).

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WebMar 20, 2024 · Cisplatin is a substrate of hOCT1 ( SLC22A1 ), hOCT2 ( SLC22A2 ), and hMATE1 ( SLC47A1 ), and oxaliplatin is a substrate of hOCT2, hOCT3 ( SLC22A3 ), … WebReducing cisplatin accumulation appears to be a major mechanism of acquired resistance. In one study, variants of an ovarian carcinoma line with increasing resistance showed decreasing levels of cisplatin accumulation, which could be measured as early as 5 min following treatment.

WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. ... In addition, more research is still needed to further clarify the potential mechanism by which USP14 regulates DDP resistance in both in vitro and in vivo models of NSCLC.

WebJun 15, 2024 · Based on the above reasons, this study mainly explored the molecular mechanism of DDP resistance in TNBC. We argue that the miR-133b-fibroblast growth factor receptor 1 (FGFR1) axis may mediate the tumor growth and DDP resistance of TNBC by regulating the Wnt-β-catenin pathway. miR-133b is related to the survival and … WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using …

WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, …

WebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decerased intracellular concentration due to decreased … tshwane west district schoolsWebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist … tshwane zoning informationWebIt has been established that the mechanism of cisplatin resistance includes reduced drug uptake, increased drug inactivation, increased DNA adduct repair, and inhibition of the … phil\u0027s stock worldWebCisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways … phil\\u0027s stock worldWebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased uptake or increased efflux; increased inactivation by intracellular proteins such as glutathione; increased repair of cisplatin adducts; increased ability to replicate past … tshwane women in transportWebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … tshwane zip codeWebApr 1, 2016 · Resistance to cisplatin occurs by the following molecular mechanisms: altered DNA repair, altered cellular accumulation of drug, and cytosolic inactivation of drug. The processes of resistance were studied in L1210 mouse leukemia cells and human ovarian cancer cells [7], [8], [9], [10]. tshwantshiso ke eng