High glucose macrophage

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August undefined, 2024

Web3 de fev. de 2024 · High-glucose concentrations are also involved in inflammatory processes ( 28, 29 ). LPS modulates the generation of an inflammatory mediator in macrophages in hyperglycemic models ( 30 ). Therefore, inflammatory responses are obviously associated with glucotoxicity in diabetic conditions. Web2 de dez. de 2024 · Macrophage marker expression of CD68, ... As an indirect support, palmitate alone or in combination with high-glucose concentrations induced NOS2 expression in islet-conditioned, ...

High glucose contributes to the polarization of peritoneal …

WebWe used C57BLKS/6J Lepdb/db mice and a high glucose (HG)-induced bone marrow-derived macrophage (BMDM) polarization system to investigate the potentially protective effects of HPS on DN. Our results showed that HPS markedly reduced diabetes-induced albuminuria and glomerular mesangial matrix expansion, accompanied with a significant … Web29 de jun. de 2024 · Here we show that LPS stimulation of RAW264.7 macrophage cells cultured in high glucose medium leads to pyroptosis, which can be suppressed by a … swivelsweeperparts.com chargers

Sustained high glucose exposure sensitizes macrophage …

Web1 de jul. de 2024 · In this article, we try to investigate whether high glucose (HG)-treated macrophages-derived exosomes could activate macrophages and induce inflammatory responses in vivo and in vitro. We incubated the exosomes from high glucose-treated Raw264.7 cells (HG-Exo) and Raw264.7 cells for 24 h. Web29 de jul. de 2007 · Macrophage inflammatory protein-3α (MIP-3α) is a CC chemokine that has been reported to attract memory T lymphocytes. Our previous microarray study showed significant increased level of MIP-3α in high glucose-induced transcriptional profile in renal proximal tubule cells. WebRegardless their exact mode of action, our findings uncovered that exosomes produced by macrophages exposed to high glucose concentrations and those isolated from the plasma of diabetic mice and human subjects carry increased levels of select microRNA including miR-486-5p that is associated with dysfunctional hematopoiesis and macrophage … swivel swing benches wooden

ScienceDirect - High glucose macrophage exosomes enhance ...

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WebThis study was, therefore, to investigate the mechanism by high glucose stimuli. Methods: In this study, Raw264.7 (murine macrophage cell line) cells were cultured and stimulated … Web7 de ago. de 2024 · High glucose levels appear to modify macrophage behaviour, affecting different aspects of diabetic and healthy BMDMs under the same LPS stimulus. Thus, hyperglycaemia leaves a glucose legacy ... swivel swift file converterWebThe macrophage membrane-camouflaged MBG NPs were then applied to load the glucose oxidase ... Nano drug delivery system constructed based on glucose oxidase is regarded to be advantageous for catalyzing the high glucose in the tumor microenvironment to produce peroxides for specific cancer treatment [25, [46], [47], [48]]. texas tech university classics

"WebHigh glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1): inhibitory … " - High glucose macrophage

High glucose macrophage

Chromatin accessibility analysis identifies the transcription factor ...

Web20 de jan. de 2024 · As shown in Figure 1A, macrophage-derived exosomal MALAT1 significantly increased from 12.5 mM to 50 mM of glucose concentration, and 25 mM high glucose had the maximal effect. Therefore, 25 mM high glucose was … Web12 de out. de 2024 · HIF-1α has been reported to be closely involved in energy metabolism and it increases the activity of glycolytic enzymes such as hexokinase-1 (HK1), 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) and lactate dehydrogenase A (LDHA) [ 17, 18 ].

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WebmiR-210 in Exosomes Derived from Macrophages under High Glucose Promotes Mouse Diabetic Obesity Pathogenesis by Suppressing NDUFA4 Expression Feng Tian, 1 Ping Tang, 1Zhilian Sun, 1Ruifen Zhang, 1Danhua Zhu, 1Junying He, 1Jixing Liao, 1Qinghua Wan, 1and Jie Shen 2 Academic Editor: Janet H. Southerland Received 02 … Web12 de abr. de 2024 · Chronic non-healing wounds, a prevalent complication of diabetes, are associated with increased mortality in diabetic patients. Excessive accumulation of M1 macrophages in diabetic wounds promotes inflammation and results in dysregulated tissue repair. Adipose tissue macrophages (ATMs) derived from healthy lean donors have the …

Web14 de mar. de 2014 · Glucose is a critical component in the proinflammatory response of macrophages (MΦs). However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating subsequent glucose metabolism in the inflammatory response are not well understood. WebNational Center for Biotechnology Information

WebHigh glucose contributes to the polarization of peritoneal macrophages to the M2 phenotype in vivo and in vitro. Glucose is the primary osmotic medium used in most … Web27 de mar. de 2024 · In addition, autophagy blockade by high glucose via the mTOR-ULK1 pathway led to severe oxidative stress response in macrophages stimulated by lipopolysaccharide. Activation of autophagy by rapamycin, clearance of mitochondrial ROS by mitoTEMPO, and inhibition of inflammasome by MCC950 could significantly reduce …

Web1 de abr. de 2024 · MAIT cell inhibition reduces inflammatory and fibrogenic genes in human PCLS. We evaluated the consequences of MAIT cell inhibition on liver fibrogenesis in human liver samples, using ex vivo PCLS ...

Web27 de ago. de 2024 · Multi-omics analysis identifies potential mechanisms by which high glucose accelerates macrophage foaming Jie Qi, Ying Lv, Ni-Er Zhong, Wen-Qi Han, Qi-Ling Gou & Chao-Feng Sun Molecular and Cellular Biochemistry 478 , 665–678 ( 2024) Cite this article 384 Accesses 5 Altmetric Metrics Supplementary Information texas tech university college texas tech university cityWeb7 de set. de 2024 · We utilized an in vitro approach to determine the effects of high glucose on macrophage phenotype. Materials and methods: We exposed human THP-1 … swivel swim platformWeb5 de mai. de 2024 · Murine macrophages were cultured in a high‑glucose in vitro environment, and the percentage of M1 macrophages in 138.8 mmol/l glucose medium … swivel swifferWeb11 de jul. de 2024 · Long-term high glucose treatment reduced macrophage glycolytic capacity and glycolytic reserve without affecting mitochondrial ATP production … swivel sys for reclinersWeb7 de set. de 2024 · Without any stimulation, macrophages cultured in high glucose conditions (15 mM, 522.6 ± 232.9 pg/mL) displayed a higher concentration of TNF-α … texas tech university college of nursingWeb18 de jul. de 2024 · Nevertheless, diabetes-induced changes in macrophage secretory products remained largely unknown. We thus analyzed high-glucose (HG)-induced changes in secretome of human macrophages derived from U937 human monocytic cell line after phorbol 12-myristate 13-acetate (PMA) activation. texas tech university data science fees