WebPhoslactomycin is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein serine/threonine phosphatase which is the protein phosphate 2A . … WebFeb 21, 2024 · ACT232 as cathepsin B inhibitors. Their structures were determined by a combination of NMR and MS data analyses to be the dephosphorylated derivatives of a …
Lactomycins A-C, Dephosphorylated Phoslactomycin Derivatives …
WebNov 10, 2012 · Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster J. Biol. Chem. (2003) B. Ostash et al. A streamlined metabolic pathway for the biosynthesis of moenomycin A Chem. Biol. (2007) O. Lazos dutch musician 550 children
Enhancement and Selective Production of …
WebA Convergent Approach toward the C1−C11 Subunit of Phoslactomycins and Formal Synthesis of Phoslactomycin B. Organic Letters, 11(4), 935–938. doi:10.1021/ol8029142 . Phoslactomycin (PLM) is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein serine/threonine phosphatase which is the protein phosphate 2A (PP2A). The PP2A involves the growth factor of the cell such as to induce the formation of mitogen-activated protein interaction … See more The domains in the polyketide synthase type I: • ACP: acyl carrier protein (serves as chaperone) • AT: acyl transferase (transfers acyl group form CoA to ACP) See more The PKS of phoslactomycin has one loading domain, 7 modules and 6 proteins that encode PnA, PnB, PnC, PnD, PnE, and PnF. The biosynthesis starts the loading with the cyclohexyl- … See more 1. ^ Klaasen and Watkins II. (2015). Casarett & Doull's Essentials of Tocicology (Third ed.). McGraw Hill, Lange. p. 29. ISBN 978-0-07-184709-4. 2. ^ "Phoslactomycin B C25H40NO8P ChemSpider" See more Isolation from Streptomyces platensis, PLM is produces. Genes PnT1 and PnT2 regulate the post-synthesis of PLM to form PLM B by the phosphorylation and added the amine group . … See more WebSep 12, 2003 · Phoslactomycins (PLMs), potent and selective inhibitors of serine threonine phosphatases, are of interest for their antitumor and antiviral activity. Multiple analogs … dutch musician fathered 550 children